View Full Version : Another study connects asymmetry and Scoliosis

14th December 2009, 05:14 AM
August 2009: Comparison of the Melatonin and Calmodulin in Paravertebral Muscle and Platelets of Patients With or Without Adolescent Idiopathic Scoliosis (http://journals.lww.com/spinejournal/Abstract/2009/08150/Comparison_of_the_Melatonin_and_Calmodulin_in.6.as px)

Conclusion. AIS group had an asymmetric distribution of calmodulin in paraspinal muscle, higher at the convex side and lower at the concave. Neither platelet melatonin nor platelet calmodulin was found to be representative of the muscle protein values.

Another study found an asymmetry in children with Scoliosis. This time the asymmetry occured in a protein called Calmodulin (http://en.wikipedia.org/wiki/Calmodulin) found in muscle cells. It should be noted that Calmodulin is significantly impacted by exercise (http://www.google.com/search?hl=en&source=hp&q=calmodulin+exercise&aq=f&oq=&aqi=).

You might be asking yourself if this Calmodulin asymmetry in the paraspinal muscles is a cause or consequence of Scoliosis. It's possible that we already have an answer. Two recent studies found that Tamoxifen (http://en.wikipedia.org/wiki/Tamoxifen), a Calmodulin antagonist puts Scoliosis in reverse.

March 2009: The Effect of Calmodulin Antagonists on Experimental Scoliosis: A Pinealectomized Chicken Model (http://journals.lww.com/spinejournal/Abstract/2009/03150/The_Effect_of_Calmodulin_Antagonists_on.2.aspx)

Conclusion. The incidence and magnitude of scoliosis in pinealectomized chicken may be decreased by the administration of TMX, presumably because of this drugs' calmodulin antagonism. Further studies on higher animals and dosage and timing are required.

April 2009: The effect of calmodulin antagonists on scoliosis: bipedal C57BL/6 mice model. (http://www.ncbi.nlm.nih.gov/pubmed/19242737)

This study has demonstrated that TMX is effective in changing the natural history of scoliotic deformities in C57BL6 mice model favorably.

8th January 2010, 08:18 AM
Hi Dingo,

Cool findings. Do you know what kinds of exercises effect calmodulin and in what way?

Also, it is important to note that TMX has side effects, and in particular is a known carcinogen (even though it can treat breast cancer) that can lead to other types of cancer (ie. uteran) and thus are usually only administered for 5 or less years.

But it would be interesting to see more radical researches done on scoliosis that target causes as opposed to finding new physical and surgical ways to "fix" it.

8th January 2010, 04:29 PM
Thanks for posting this information. I'd also be interested to learn which exercises might address the assymetry. My daughter has been doing PT for 6 months but the weaker side is still weak. The exercises don't seem to have addressed the difference in muscle strength at all.

8th January 2010, 04:32 PM
Veevee and aterry

Do you know what kinds of exercises effect calmodulin and in what way?

I believe that all exercise impacts Calmodulin.

However the specific exercises that scientists are looking at involve the paraspinal muscles. 3 different studies have found that torso rotation is an effective treatment for childhood Scoliosis. Here is a link to the first study published by Dr. Vert Mooney, a spine surgeon in California. On page 4 is a chart that lists the curves before and after PT. I should note that these children only worked out twice per week and for just a few minutes each time. According to Dr. Mooney that's all it takes. In the study they used a MedX machine but I'm not sure if it matters which machine is used as long as the pelvis sits stable during movement. This exercise can even be done without a machine by using an exercise band and a chair. Dr. McIntire explained how to do that in his 2008 study on torso rotation.

The Role of Measured Resistance Exercises in Adolescent Scoliosis (http://www.medxonline.com/downloads/articles/measuredresistanceinscoliosis.pdf)

Here is a news video about an 8 year old girl who used this PT to treat her Scoliosis. (http://www.wcsh6.com/news/health/story.aspx?storyid=92954&catid=8)

You are right about TMX and Scoliosis. It may or may not be an effective treatment but it provides scientists with evidence that Calmodulin is part of the problem.

6th March 2010, 07:30 AM

I found a torso rotation machine at the gym at my university ^^. The information sheet says it targets the abs but I'm hoping it also helps the back. I watched the video, it was very interesting.

All the best of luck to you!


6th March 2010, 02:15 PM
Hello Veevee and Aterry, welcome to SSO :welcome2:

Aterry, there is no need to pretend that you haven't already discussed torso rotation therapy with Dingo on another forum. Peaceful and accurate discussions are always welcome :)

Toni xx